Fig. 7: The differences in gene expression and biological process from HEC and pre-HSCs after Atg5 depletion.
From: Autophagy regulates the maturation of hematopoietic precursors in the embryo
a–c Volcano graphs showing the up/down regulated genes in the KO HEC (a), pre-HSC I (b) and pre-HSC II (c) compared to control. Some up or down regulated genes were indicated. d–f Top 15 differentially expressed genes (DEGs) in the HEC (d), pre-HSC I (e) and pre-HSC II (f) compared KO with control group by scaled gene expression. g–i The enriched genes related to the biological processes are involved in the hematopoietic regulation and autophagy related process in the HEC (g), pre-HSC I (h) and pre-HSC II (i). KO vs control, p < 0.05. j The normalized enrichment scores (NES) of KEGG pathways by GSEA analysis showing the alteration of ubiquitin-mediated proteolysis, and oxidative phosphorylation in the EC, pre-HSC I and pre-HSC II after Atg5 deletion.
