Fig. 1: Workflow to characterise the global population structure of Streptococcus dysgalactiae subsp. equisimilis (SDSE) and its overlap with S. pyogenes. | Nature Communications

Fig. 1: Workflow to characterise the global population structure of Streptococcus dysgalactiae subsp. equisimilis (SDSE) and its overlap with S. pyogenes.

From: Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

Fig. 1

A globally diverse collection of 228 SDSE isolates were whole genome sequenced using Illumina short read sequencing and collated with publicly available genomes to form a database of 501 global sequences. An analysis of the SDSE population structure was undertaken followed by a systematic analysis of the pangenome, evidence of homologous recombination, mobile genetic elements (MGEs) and MGE insertion sites using pangenome gene synteny contextual information. This framework was then compared with a previously published global database of 2,083 S. pyogenes genomes by merging pangenomes accounting for shared gene synteny to reveal extensive overlap at the level of shared genes, homologous recombination and MGEs22. Figure created with BioRender.com.

Back to article page