Fig. 2: MapUTR identifies functional rare 3′ UTR variants regulating mRNA abundance. | Nature Communications

Fig. 2: MapUTR identifies functional rare 3′ UTR variants regulating mRNA abundance.

From: Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes

Fig. 2

a Average mismatch rate (%) in DNA-seq and RNA-seq libraries. b Correlation of activity scores between biological replicates in HEK293 and HeLa respectively. P-value is based on a two-sided Spearman correlation test. c Relative activity scores and FDR of all rare 3′ UTR variants tested in HEK293 (top) and HeLa (bottom). d Relative activity scores and FDR of clinically relevant rare 3′ UTR variants tested in HEK293 (left) and HeLa (right). e Correlation of relative activity of functional variants common to HEK293 and HeLa cells. P-value is based on a two-sided Spearman correlation test. a–e Source data are provided as a Source Data file.

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