Fig. 4: Viral load analysis following ECTV challenge and mAbs treatment. | Nature Communications

Fig. 4: Viral load analysis following ECTV challenge and mAbs treatment.

From: Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

Fig. 4

Viral titers were determined by plaque assay from the indicated organs (spleen, liver, and lung) of BALB/c mice, eight dpi with 50 PFU i.n. ECTV. Viral loads are presented for mice treated at three dpi. (A, C and E) and at five dpi. (B, D and F). Horizontal lines represent the mean of each group (indicated above each line). Dashed line represents limit of detection (LOD). Samples below the LOD assigned a value of half of the LOD. Asterisk denote for significant reduction in viral load compared to the BLN12 (isotype control treated group) using Mann-Whitney non-parametric two-tailed unpaired T test (n  =  4, *P = 0.03). The error bars represent the SEs. Source data are provided as a Source data file.

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