Fig. 1: Study overview.
From: Large-scale cross-ancestry genome-wide meta-analysis of serum urate
Overview of this study. Six GWAS summary statistics were used for the meta-analysis of the ancestry-specific study. In the cross-ancestry study, previously unreported loci were identified by a meta-analysis of CKDgen, UKBB, and KoGES summary statistics. The European ancestry study performed a meta-analysis of CKDgen (European) and UKBB (European) summary statistics, whereas the East Asian ancestry study performed a meta-analysis of BBJ and KoGES. In this ancestry-specific meta-analysis, post-GWAS, such as functional enrichment, PRS, and eQTL analyses, were performed separately for each meta-analysis. GWAS genome-wide association study, SNP single-nucleotide polymorphism, LDSC linkage disequilibrium score regression, PRS polygenic risk score, pheWAS phenome-wide association study, MR Mendelian randomization, SMR summary-based MR, UKBB UK BioBank, CKDgen Chronic Kidney Disease Genetics Consortium, KoGES Korean Genome and Epidemiology study, BBJ Biobank Japan.
