Fig. 3: The tissue enrichment analysis in cross-ancestry meta-analysis and gene-set enrichment analysis in ancestry-specific meta-analysis for serum urate-associated loci.
From: Large-scale cross-ancestry genome-wide meta-analysis of serum urate
a Tissue enrichment related to SU-associated loci in cross-ancestry meta-analysis is shown by tissue groups into physiological systems. The x-axis represents tissues grouped by physiological systems, and the y-axis represents -log10 (P-value). The orange color indicates significantly enriched tissues and labels (FDR < 0.05). P-values were determined using a two-sided test. b For the meta-analysis results for each ancestry, gene-set enrichment was performed using GSA-SNP2. The enrichment in the canonical pathway gene sets of databases such as KEGG (Kyoto Encyclopedia of Genes and Genomes), NABA (Matrisome Project), and REACTOME (Reactome Project) was investigated using MSigDb c2.cp.v6.2. Only significantly enriched gene sets with q-value < 0.25 are shown after FDR correction. SU serum urate, FDR false discovery rate.
