Fig. 5: Phenome-Wide Association Study (PheWAS) of cross-ancestry PRS in the UKBB participants of European ancestry. | Nature Communications

Fig. 5: Phenome-Wide Association Study (PheWAS) of cross-ancestry PRS in the UKBB participants of European ancestry.

From: Large-scale cross-ancestry genome-wide meta-analysis of serum urate

Fig. 5

PheWAS plot for 1621 UKBB phecodes using PRS derived from cross-ancestry meta-analysis results. The x-axis represents each phecode divided into 17 categories, and the y-axis represents the log10 of uncorrected P-values for linear regression between SU PRS and each phecode. A triangular dot indicates a phenotype with a positive odds ratio, and an inverted triangular dot indicates a phenotype with a negative odds ratio. The upper dotted line represents the threshold for Bonferroni’s correction (P = 3.08 × 10−5), and the lower dotted line represents a P-value of 0.05. PRS polygenic risk score, SU serum urate, UKBB UK BioBank.

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