Fig. 4: Mutation of the Hmg1 SSD specifically alters response to triazoles and not allylamines or statins.
From: A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
A Schematic of the mevalonate and ergosterol biosynthesis pathways highlighting enzymatic steps inhibited by statins (rosuvastatin), allylamines (terbinafine), and triazoles (voriconazole). Illustration prepared using BioRender.com. Radial growth assays of the parental and manipulation controls and the Hmg1 SSD mutants to assess susceptibility changes are shown for rosuvastatin (B), terbinafine (C), and voriconazole (D). Conidia (5 × 103) from each strain were spot inoculated onto RPMI media (0.2% glucose, pH 7.0) containing the indicated amount of drug and plates were cultured for 72 hours at 37 °C. Source data are provided as a Source Data file.
