Fig. 2: Proteomic cohort characteristics and sample workflow.

a Schematic overview of the different steps of randomization; samples were randomized twice, at the stage of the protein extraction (keeping pairs and samples from the same patient together) and before tag labelling (again keeping pairs and patients together but randomizing across the tag channels); red and blue indicate tumor and healthy samples, respectively, spectral colors indicate pathological stages, arcs connect sample pairs; grey is the 134 N pooled reference standard; TMT: tandem mass tags; b Number of identified proteins across the different TMT sets of high and low peptide concentrations; dashed line shows the number of commonly identified proteins across the number of TMT sets. Source data are provided as a Source Data file.