Fig. 6: Drug repurposing and predictive correlation with the proteomic subtypes.

Heatmaps of the frequencies of the in silico CMap predictions of a pathways and b drugs based on n = 180 qualitative profiles of up and downregulated proteins; asterisk: investigated in vitro. c In vitro dose-response curves of n = 12 urothelial cancer cell lines, which were selected as a functional UC panel and classified within the PAULA scheme; all cell lines were treated with exemplary compounds from the in silico predictions from A; dots are single data points, line is the fitted Hill function used to calculate half-maximal inhibitory concentrations (IC₅₀); colors as in d. d IC₅₀ values of the cell lines from C; in ascending order, bar base is 1 µM as indicator of sensitivity (bar downwards = more sensitive); color is predicted PAULA cluster based on RNA data, opacity is prediction confidence (cluster probability); p = (two-sided Kruskal-Wallis of sorted order, two-sided Mann-Whitney-U of quantitative values). Source data are provided as a Source Data file.