Fig. 1: Overview of the samples collection, processing, and our analysis pipelines for WGS and single cell multiomics (created by BioRender).

Samples were collected from SMM, NDMM, and RRMM patients and sorted into the CD138+ fraction. This fraction was then split and sent for bulk WGS and single cell multiomic (RNA + ATAC) sequencing. These cells and patient WGS profiles then underwent our computational pipeline.