Fig. 3: Differential expression for the top intersecting RRPC₁₁, RRPC₂₀, and RRPC₂₂ markers.

A Heatmap of the top 90 up-regulated DEGs common between RRPC₁₁, RRPC₂₀, and RRPC₂₂. The DEGs were sorted by their rank sum across RRPC₁₁, RRPC₂₀, and RRPC₂₂. B RRPC clusters coexpress PHF19 and MKI67. C PHF19 and MKI67 expression are correlated in their expression (PCC P ≈ 0.00). Note that expression values were smoothed using 20 nearest neighbors for visualization purposes in B and C. D–F Top 15 significant (one-sided Fisher’s exact test and BH-corrected) GO Biological Process for RRPC₁₁ DEGs (FDRs top to bottom: 2.38E−44, 2.38E−44, 3.66E−36, 6.61E−37, 2.13E−41, 1.25E−51, 2.32E−34, 3.41E−36, 3.07E−37, 4.38E−36, 1.04E−38, 4.02E−37, 5.41E−35, 1.03E−45, 2.71E−34) (D), RRPC₂₀ DEGs (FDRs top to bottom: 3.38E−37, 9.82E−37, 6.19E−28, 2.39E−29, 8.27E−35, 8.23E−33, 3.72E−32, 3.24E−31, 1.85E−27, 1.60E−22, 5.37E−32, 8.35E−31, 1.73E−22, 8.04E−31, 7.20E−30) (E), and RRPC₂₂ DEGs (FDRs top to bottom: 8.48E−48, 2.02E−30, 7.17E−31, 1.33E−32, 3.38E−43, 1.21E−28, 1.77E−27, 5.25E−35, 3.55E−35, 1.44E−38, 5.54E−43, 2.89E−30, 7.93E−35, 5.94E−38, 4.44–36) (F).