Fig. 3: Distribution of CRs found in Houston wastewater.
From: Crykey: Rapid identification of SARS-CoV-2 cryptic mutations in wastewater
In both a and b, the locations of CRs on the SARS-CoV-2 reference genome found in Houston wastewater samples are shown on the x-axis, with SARS-CoV-2 ORFs shown above the figure panels. In panel a, each CR is represented by a colored dot, the y-axis indicates its mean AF in the wastewater sample, and the color indicates its rarity, defined as –log10((n+1)/N), where n is the number of genomes supporting the CR in the GISAID EpiCoV database, and N is the total number of sequences in GISAID; the larger the number the rarer the mutation in GISAID. The darker color suggests that the CR is rare or unreported. The size of the dot shows the number of weeks the CR was detected. Larger dots indicate the CR persisted longer in the community. Panel b is a histogram showing the count of CRs found in different 400 bp regions of the reference genome. CRs containing exclusively non-synonymous mutations are marked in orange, and the CRs containing at least one synonymous mutation are marked in gray. Higher bars indicate that more CRs were found in the associated region. Source data are available for this figure and are provided in the Source Data file.
