Fig. 4: CORVET-specific Vps8-Vps11 N-terminal interface. | Nature Communications

Fig. 4: CORVET-specific Vps8-Vps11 N-terminal interface.

From: Structure of the endosomal CORVET tethering complex

Fig. 4

A Molecular models of CORVET Vps8 and Vps11 in ribbon representation fitted into the semi-transparent low-pass-filtered consensus cryo-EM map colored by subunits as in Fig. 1. B, C Zoomed-in views of the interface sites between Vps8 and Vps11 with interacting structural elements indicated. Associated semi-transparent cryo-EM densities are zoned around the molecular models and colored accordingly. D Representative cryo-EM 2D class averages of CORVET wild-type and Vps11ΔN mutant. Structural differences in the regions of Vps8 and Vps11 N-termini are indicated. E Comparison of CORVET wild-type and Vps11ΔN mutant cryo-EM densities colored by subunits as in Fig. 1. The mutant cryo-EM density is overlayed on the wild-type density (transparent, black outline) highlighting the structural differences.

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