Fig. 6: Mechanistic model of membrane tethering by CORVET and HOPS within the endolysosomal pathway. | Nature Communications

Fig. 6: Mechanistic model of membrane tethering by CORVET and HOPS within the endolysosomal pathway.

From: Structure of the endosomal CORVET tethering complex

Fig. 6

CORVET is responsible for early-endosomal fusion events and selectively relies on the Rab5 (Vps21) and phosphatidylinositol-3-phosphate (PI3P) presence in the membranes for function. In contrast, the lysosomal tether HOPS requires Rab7 (Ypt7) and, potentially, different lipid composition (e.g. phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)) to promote membrane fusion. The cartoon, including the SNARE proteins, Rab GTPases, and membranes, is not drawn to scale.

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