Fig. 2: Selective deletion of ASIC3 in nociceptors suppresses skin inflammatory phenotype and cytokine induction in psoriasis.
From: Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
a Spleen weight of Asic3flox/flox mice and NaV1.8Cre::Asic3 flox/flox mice. **p = 0.0027 < 0.01, two-tailed unpaired Student’s t test. b Representative H&E staining of lesional skin from conditional ASIC3 knockout mice treated with IMQ. Scale bar, 200 μm. c Representative Ki67 staining of lesional skin from conditional ASIC3 knockout mice treated with IMQ. Scale bar, 200 μm. d Quantification of epidermal thickness in (b). ***p = 5.1451E−8 < 0.001, two-tailed unpaired Student’s t test. e Quantification of Ki67 positive cells in (c). **p = 0.0031 < 0.01, two-tailed unpaired Student’s t test. f Psoriasis-related cytokine IL-17, IL-22, and IL-23 protein expression in lesional skin of Asic3flox/flox and NaV1.8Cre::Asic3 flox/flox mice. IL-17: **p = 0.0035 < 0.01; IL-22: *p = 0.0175 < 0.05; IL-23: **p = 0.0027 < 0.01, two-tailed unpaired Student’s t test. n = 10 mice per group. Summary data are mean ± SEM.
