Fig. 6: In vivo hemostatic effect of alkylated-superporous chitosan sponge (A-spCS) in SD rats.

a Schematic diagram of the rat liver perforation model and the hemostasis process. b Photographs of hemostatic effects of blank, gauze, gelatin sponge (GS), CELOX, CELOX-E, chitosan sponge (CS), porous chitosan sponge (pCS), superporous chitosan sponge (spCS), and A-spCS. The yellow dotted line is the boundary of the liver. c, d Total blood loss and hemostasis time of blank, gauze, GS, CELOX, CELOX-E, CS, pCS spCS, and A-spCS groups. Values and error bars in (c, d) represent the mean and standard deviation (n  =  3 independent samples), P > 0.05 (ns), **P < 0.01, ***P < 0.001, ****P < 0.0001 (Two-tailed Student’s t test to compare two groups).