Fig. 9: TOGARAM2 contributes towards TAZ-driven oncogenicity.
From: The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer
A Representative western blots of TAZ KD HeLa cell lysates transfected with pcDNA3 or FLAG-TOGARAM2 probed for TAZ, FLAG and GAPDH loading control (n = 3). B Growth curve analysis of TAZ KD HeLa cell lysates transfected with pcDNA3 or FLAG-TOGARAM2 (n = 3). C Colony formation assay of TAZ KD HeLa cell lysates transfected with pcDNA3 or FLAG-TOGARAM2 (n = 4). D Soft agar assay of TAZ KD HeLa cell lysates transfected with pcDNA3 or FLAG-TOGARAM2 (n = 4). E Transwell migration assay of TAZ KD HeLa cells transfected with pcDNA3 or FLAG-TOGARAM2 (n = 3). F Cell Invasion assay of TAZ KD HeLa cells transfected with pcDNA3 or FLAG-TOGARAM2 (n = 4). G Immunofluorescence microscopy analysis of Rhodamine-Phalloidin stained (red) TAZ KD HeLa cells transfected with pcDNA3 or FLAG-TOGARAM2. DAPI stained nuclei (blue). Scale bar 10 µm. H Measurement of filopodia length in TAZ KD HeLa cells transfected with pcDNA3 or FLAG-TOGARAM2 (n = 10). I Average number of filopodia per cell in TAZ KD HeLa cells transfected with pcDNA3 or FLAG-TOGARAM2 (n = 10). Error bars represent the mean +/- standard deviation of a minimum of three biological repeats. *P < 0.05, **P < 0.01, ***P < 0.005 (two-tailed, unpaired Student’s t-test). Source data are provided as a Source Data file.
