Fig. 2: The ATAS provides precise and stable extracorporeal circulation and highly efficient separation for apheresis.

a Schematic view showing the structure of the fluid stabilizer used in the ATAS to generate a steady flow rate. b Mechanism and simulation of the fluid stabilizer show that the input flow's fluctuation amplitude is decreased via passing by the cavities connected beside the main channel. c Experimental results show the comparison of the input flow rate and output flow rate of the fluid stabilizer as a function of time. d The calibration data of flow rate adjustment of the peristaltic pumps used in the ATAS. e Comparison of the ATAS and commercial syringe pump regarding flow stability by injecting fluorescent and non-fluorescent water into the Y-shape channel. Characterization of the red blood cell (RBC) and platelet recovery rate after ATAS processing under varied f flow rates and g input voltages. Data represent the mean ± SD; n  =  3 (flow rates) and 3 (input voltages). h Microscopy images show the separation of cellular components from plasma using the ATAS when a fluid stabilizer is not equipped or equipped. Distribution of i RBCs and j platelets in the samples collected from the cell and plasma outlets. Data represent the mean ± SD; n  =  3 (RBCs) and 3 (platelets). The statistical analysis was performed using a two-sided Student’s t-test. Data are graphed as the mean ± SD. Source data are provided as a Source Data file.