Fig. 3: NPAS4 functions in NAc D2-MSNs to promote cocaine-seeking behaviors. | Nature Communications

Fig. 3: NPAS4 functions in NAc D2-MSNs to promote cocaine-seeking behaviors.

From: NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens

Fig. 3

A Experimental design using Cre-dependent Npas4 shRNA in D1- or D2-Cre mice (CPP) and rats (IVSA). B Timeline of cocaine CPP and locomotor sensitization. C Cocaine CPP in D1-Cre (n = 11, 12 mice/group) and (D) D2-Cre mice (n = 11, 12 mice/group; unpaired t-test, t = 3.578, df = 21, p = 0.0018). E Timeline of cocaine SA. F Lever presses during acquisition of cocaine SA following NPAS4 knockdown in D1-Cre (n = 6 rats/group) and (G) D2-Cre rats (n = 8 rats/group). H Cue-induced reinstatement of cocaine seeking in D1-Cre (n = 6 rats/group) and (I) D2-Cre rats (n = 8 rats/group; two-way RM ANOVA with multiple comparisons, p = 0.0003). Data shown are mean ± SEM; **p < 0.01, ***p < 0.001. Source data are provided in the Source Data file.

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