Fig. 6: IL13-IL13RA1 is the most significant ligand–receptor pair among IL4 signaling pathways in PBMC and blister scRNA-seq datasets. | Nature Communications

Fig. 6: IL13-IL13RA1 is the most significant ligand–receptor pair among IL4 signaling pathways in PBMC and blister scRNA-seq datasets.

From: Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease

Fig. 6

a UMAP visualization of the PBMCs scRNA-seq profile. b Circle plot of the inferred IL4 signaling pathway in PBMC samples from the BP and HC groups. c Comparison of the multiple ligand–receptor pairs among IL4 signaling pathway in PBMCs. d UMAP visualization of the cells from blister scRNA-seq profile. e Expressions of major discriminative marker genes for cell types identification of blister scRNA-seq dataset. f Circle plot of the inferred IL4 signaling pathway in blister samples from the BP group. g Comparison of the multiple ligand–receptor pairs among IL4 signaling pathway in blister cells. P-values in c and g were computed from one-sided permutation test (CellChat 1.5.0).

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