Fig. 2: SARS-CoV-2 infection of AGM is associated with elevation and persistence of blood glucose concentration even after undetectable virus.

a Levels of plasma glucose following infection over time. PERMANOVA analysis was used for statistical analysis to examine the cumulative difference between glucose levels in the two groups over time. Unvaccinated: n = 10; Vaccinated: BL-Wk 8, n = 5; Wk 9-Wk 17, n-4. b Pie charts showing the proportion of animals with glucose >100 mg/dL at baseline (BL) and week 1, 4, 12 and 16. Unvaccinated: n = 10; Vaccinated: BL- Wk 4, n = 5; Wk 9-Wk 16, n = 4. c Glucose levels at BL and week 1, 4, 12 in unvaccinated animals (n = 9) post infection (p.i.), analyzed using Two-tailed Wilcoxon matched pairs signed-rank test. d Two-sided Spearman correlation between glucose levels and subgenomic nucleocapsid (N) and genomic N at day 3 post infection in all animals. e IgA response against NC (n = 5) and S1RBD (n = 4) at Wk 3 against unvaccinated animals with low and high glucose in the preceding week (week 2), analyzed using Two-tailed Man Whitney T test. f Triglyceride levels over time between to the vaccinated and unvaccinated group. Unvaccinated: n = 10. Vaccinated: BL-Wk 8, n = 5; Wk 9-18, n = 4. PERMANOVA was used for statistical analysis. g Triglyceride levels at BL and week 1, 4, 12 in unvaccinated animals (n = 9) p.i., analyzed using Two-tailed Wilcoxon matched pairs signed-rank test. h Total cholesterol levels between the unvaccinated and vaccinated group. Unvaccinated: n = 10. Vaccinated: BL-Wk 8, n = 5; Wk 9-18, n = 4. i Cholesterol levels at BL and week 1, 4, 12 in unvaccinated animals (n = 9) p.i., analyzed using Two-tailed Wilcoxon matched pairs signed-rank test. Key: BL1 = baseline 1 (6.5 weeks pre-infection); BL2 = baseline 2 (11 days pre-infection); d3 = day 3. PERMANOVA was used to compare groups in a, f. Error bars represent SEM. n denotes number of independent samples/animals at each timepoint. Source data are provided as a Source Data file.