Fig. 5: RNF213-regulated Treg differentiation in a FOXO1-dependent manner. | Nature Communications

Fig. 5: RNF213-regulated Treg differentiation in a FOXO1-dependent manner.

From: RNF213 promotes Treg cell differentiation by facilitating K63-linked ubiquitination and nuclear translocation of FOXO1

Fig. 5

A Schematic of experimental design for multiple transgenic mice. B The graph shows the clinical score of EAE (n = 5 per group). C Concentration of IL-17 and IL-10 in serum was measured by ELISA on day 20. D Flow cytometry of Treg cell (CD25+ Foxp3+) in CNS on days 20 during EAE. Pooled data are presented in the right panel. Data shown are the mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001. P values were calculated using a two-sided, unpaired Student’s t-test in (B–D). N = 5 (C), n = 3 (D) repeats from three independent experiments. Source data are provided as a Source Data file.

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