Fig. 4: Differential transcript expression associated with the progression of tau pathology in TG mice. | Nature Communications

Fig. 4: Differential transcript expression associated with the progression of tau pathology in TG mice.

From: Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology

Fig. 4

A Transcript expression (ONT full-length read counts) of the 12 significantly upregulated transcripts in TG mice (black) associated with the progression of tau pathology and B the two top-ranked endogenous Mapt transcripts significantly up-regulated in TG compared to WT mice. Plots in A and B are ordered by significance. C Structure of these 14 transcripts alongside reference transcripts for each gene. Transcripts are color-coded by gene, with shading indicating significance (darker indicates greater significance). SQANTI3 structural categories (FSM full splice match, ISM incomplete splice match, NIC novel in catalog, NNC novel not in catalog) are provided in parenthesis for each transcript.

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