Fig. 3: CPMG-RD study on Meis1-HD bound to DNA. | Nature Communications

Fig. 3: CPMG-RD study on Meis1-HD bound to DNA.

From: Molecular basis of facilitated target search and sequence discrimination of TALE homeodomain transcription factor Meis1

Fig. 3

a Representative scheme for the non-specific and specific binding modes of Meis1-HD. The letters F, NB, and SB indicate the free, non-specific binding, and specific binding states of Meis1-HD, respectively. b 15N CPMG-RD data for the representative residues: (upper) F279 and V282 (L1-α1 region) and (lower) I324 and S338 (α3-L4 region) of Meis1-HD–WT meisDNA complex determined at 800 MHz. Solid lines indicate the global best-fit for the CPMG data using Eq. 5. c Quantitative description of the energy landscape of the specific (red) and non-specific (blue) binding of Meis1-HD to WT meisDNA.

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