Fig. 1: Mapping of structural variations at Diagnosis and Relapse using Hi-C. | Nature Communications

Fig. 1: Mapping of structural variations at Diagnosis and Relapse using Hi-C.

From: Clonal evolution of the 3D chromatin landscape in patients with relapsed pediatric B-cell acute lymphoblastic leukemia

Fig. 1

a Entire genome Hi-C contact matrix for patient PATIKJ. b Zoomed in Hi-C contact matrix demonstrating BCR-ABL1 translocation between chromosome 9 and chromosome 22 in patient PATIKJ at diagnosis and at relapse (left and right respectively). c Reconstructed Hi-C contact matrix presenting an example of a shared BCR-ABL1 translocation in patient PATIKJ between chromosomes 9 and 22 at diagnosis and relapse (left and right respectively). Green dashed triangle highlights a NeoTAD. d Translocations and their log-odds score identified in diagnosis and relapse per patient. Those also found by cytogenetics or fusion transcripts are marked.

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