Fig. 1: Epigenome-wide association study of incident ACS in the Dongfeng–Tongji cohort. | Nature Communications

Fig. 1: Epigenome-wide association study of incident ACS in the Dongfeng–Tongji cohort.

From: Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome

Fig. 1

a Manhattan plot. The 26 validated CpGs associated with incident ACS are shown in red dots. We labelled genes mapped to the 26 validated CpGs, with 3 mapped to known cardiovascular disease genes labelled in red text. b QQ plot. The QQ plot illustrates the distribution of observed P values compared to expected values under the null hypothesis of no association. λ is the genomic inflation factor. c Volcano plot. The x-axis shows the effect size of each CpG (raw M value) associated with incident ACS, whereas the y-axis indicates –log10 (P) of the associations. The 7 hypermethylated CpGs with FDR < 0.05 are shown in red dots, and the 65 hypomethylated CpGs with FDR < 0.05 are shown in blue dots. For Manhattan plot and volcano plot, the horizontal solid line corresponds to the genome-wide significance threshold after multiple testing correction (FDR < 0.05), and the horizontal dashed line corresponds to the significance threshold of Bonferroni-corrected P < 0.05. The P value and FDR are calculated using two-sided tests. ACS acute coronary syndrome, CpG cytosine-phosphate-guanine, FDR false discovery rate.

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