Fig. 3: Psoriasis-related genetic variants on gene biological functions and expression patterns in tumors. | Nature Communications

Fig. 3: Psoriasis-related genetic variants on gene biological functions and expression patterns in tumors.

From: An observational and genetic investigation into the association between psoriasis and risk of malignancy

Fig. 3

A, B Enriched GO terms and KEGG pathways in genes mapped from psoriasis-related SNPs. Scatter diagram illustrating the distribution of the −log10(p values) and the enrichment factor (the ratio of enriched genes to the total input genes). The red dots on the diagram indicate associations with the inflammatory response and DNA repair pathways. The size of the dots corresponds to the enrichment factor, with larger dots indicating higher enrichment levels. C The expression distribution of genes in lung cancer tissues (n = 1013) and normal tissues (n = 287). D The expression distribution of genes in breast cancer tissues (n = 1099) and normal tissues (n = 179). The abscissa represents different genes, and the ordinate represents the expression distribution of miRNA (log2(normalized count + 1)). Box plots display the median (center line), 25th and 75th percentiles (box bounds), and minimum and maximum values (whiskers). Different colors represent distinct groups. The statistical difference between the two groups was compared through Welch’s t-test. Exact p values for each gene are provided in Supplementary Tables 28 and 29. *p < 0.05, **p < 0.01, ***p < 0.001, ns not significant. All statistical tests are two-sided and unadjusted for multiple comparisons. GO gene ontology, KEGG Kyoto Encyclopedia of Genes and Genomes. Source data are provided as a Source Data file.

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