Fig. 4: The active conformation of FZD4 and DEP. | Nature Communications

Fig. 4: The active conformation of FZD4 and DEP.

From: Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation

Fig. 4

a A comparison of the overall structures of the inactive FZD4 (PDB: 6bd4), DEP-bound FZD4 and active SMO (PDB: 6ot0). b A comparison of the conformation change of the micro switch between the inactive receptor and active receptors. c A comparison of DEP conformation in solvent (PDB: 1fsh) and its conformation in engaging FZD4.

Back to article page