Fig. 6: FZD4 dimerization interface.

a A hydrophobic surface analysis of the FZD4 dimer. b FZD4 uses its TM2, TM3 and TM4 as primary interface to form the dimer. c–f Comparisons of the FZD4 cryo-EM dimer with the FZD4 crystal symmetry dimer (PDB: 6bd4), SMO dimer (PDB: 4jkv), APJR dimer (PDB: 7w0l) and GABA_B dimer (PDB: 6w2y).