Fig. 2: GV-971 modifies gut microbial richness and community structure in mice during SAP.
From: GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis
a Cecal contents were collected from various groups, including control mice (CON, n = 8 samples), mice with SAP (SAP, n = 8 samples), and SAP mice pre-treated with a high dose of GV-971 (HG + SAP, n = 8 samples). Analysis was conducted using the Illumina MiSeq platform. The Venn diagram and its corresponding bar plot are based on ASV levels in different groups. b Principal coordinate analysis based on ASV level in different groups (n = 8 samples). c Bar plots illustrating differential bacterial richness at the genus level in different groups (n = 8 samples). d A two-tailed Spearman correlation heatmap showing the differential genera and their relationships with pancreatic function indicators between the SAP group and HG + SAP group. Positive correlations are denoted in red, while negative correlations are in blue. e The symbiotic network illustrating relationships among the differential genera between the SAP group and HG + SAP group. Data are presented as mean ± SD. Statistical comparisons were conducted using one-way ANOVA with Dunnett’s test for statistical significance. Source data are provided as a Source Data file. PCoA principal coordinate analysis, ASV amplicon sequence variant, Cor correlation coefficient.
