Fig. 3: B. acidifaciens protects against intestinal inflammation and barrier dysfunction. | Nature Communications

Fig. 3: B. acidifaciens protects against intestinal inflammation and barrier dysfunction.

From: Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis

Fig. 3

After a week of acclimation, 8-week-old male C57BL/6 J mice (n = 6 per group) were subjected to daily oral gavage of PBS or 2 × 108 CFU B. acidifaciens for three weeks. Colitis was induced in mice by providing 3% DSS in the third week. a, b Study design and body weight change in DSS-treated mice with/without B. acidifaciens treatment. c–e The length, H&E staining, Alcian blue staining, and histological damage score of the colon in DSS-treated mice with or without B. acidifaciens treatment. f, g Relative protein expressions of tight junction proteins in the colon and serum concentrations of pro-inflammatory cytokines of DSS-treated mice with or without B. acidifaciens treatment. Samples for western blot were derived from the same experiment and gels/blots were processed in parallel. One-way ANOVA with Tukey’s test was used for statistical analysis. Data were presented as mean ± SEM. Source data were provided as a Source Data file.

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