Fig. 9: B. acidifaciens and pentadecanoic acid (C15:0) are downregulated in UC patients and LPS-challenged piglets. | Nature Communications

Fig. 9: B. acidifaciens and pentadecanoic acid (C15:0) are downregulated in UC patients and LPS-challenged piglets.

From: Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis

Fig. 9

a–c Relative abundances of B. acidifaciens, the C15:0 concentrations, and their correlation in the feces of healthy volunteers (n = 15) and UC patients (n = 11) admitted to Jiangyin People’s Hospital affiliated with Nantong University (Jiangsu, China) in 2023. d–f Relative abundance of B. acidifaciens (n = 6 per group), the C15:0 concentrations (n = 6 per group), and their correlation in the feces of piglets with and without LPS challenge. g–i Several publicly available metabolomic datasets from China, USA, Netherlands, and Norway were reanalyzed, showing the concentrations of C15:0 in the feces, serum, and colonic biopsy of healthy controls (n = 503) and UC patients (n = 649). j–l Active and inactive UC patients were further selected from the same large metabolomic datasets and analyzed for relative concentrations of C15:0 in the feces, serum, and colonic biopsy of inactive UC (n = 408) and active UC (n = 167) patients. The boxplot (a, b, g–l) displays the distribution of concentrations for each metabolite, with the box representing the interquartile range (5th to 95th percentiles), the center line representing the median, and the whiskers representing the minimum and maximum values. Unpaired two-tailed Student’s t test was used for (d, e), and two-sided Mann-Whitney U test was used for (a, b, g–l). Spearman’s two-tailed correlation was used for(c, f). Data were presented as mean ± SEM. Source data were provided as a Source Data file.

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