Fig. 4: Metabolic profiles of craniotomy and prosthetic joint infection (PJI) microenvironments are temporally diverse.
From: Tissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection
The dataset from Fig. 3 was reanalyzed to assess temporal changes within each infection site over time. A–C The percentage of significantly altered extracellular metabolites among all detected chemical species across time within each niche and D–F PCA was used to illustrate metabolic heterogeneity between time points within infection sites. G–I Metabolites changed over time are presented as heat maps of log-transformed normalized peak intensities. Data analyzed by MetaboAnalyst using one-way ANOVA and only significant comparisons are shown (p < 0.05). Source data are provided as a Source Data file.
