Fig. 6: Quantitative enrichment analysis of spatial and temporal comparisons reveals significant metabolic pathways in flux between craniotomy and PJI.
From: Tissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection
Quantitative enrichment analysis for both extracellular tissue (A, B) and granulocyte (C, D) metabolomic comparisons performed in Figs. 3, 4, and 5 are shown. Enrichment ratios were calculated by the number of significantly differentially detected metabolites as a fraction of total pathway constituents. Craniotomy vs. PJI comparisons (A, C) were conducted using categorical/classification grouping, while timeseries comparisons (B, D) were analyzed by continuous regression. A–D Data analyzed with MetaboAnalyst Enrichment tests based on well-established globaltest116 methodology. Significant pathways are shown in graded colors (p < 0.05), whereas non-significant pathways are depicted in gray and fall left of the significance line. Source data are provided as a Source Data file.
