Fig. 5: Odds-ratio plots for relationship between PC PRS and cardiometabolic diseases.
From: Genetic basis of right and left ventricular heart shape
Bar plots illustrating the odds ratios from the logistic regression of PC-derived PRS against the incidence of cardiometabolic diseases, after adjusting for relevant covariates (n = 371,264). A vertical blue dotted line is plotted at an odds-ratio of 1, with each individual disease having an odds-ratio plotted as a central vertical line and orange point, and confidence interval lines flanking as an intersecting horizontal line denoting 95% confidence intervals. PC, principal component; OR, odds ratio; PRS, polygenic risk score; MI, myocardial infarction; HF, heart failure; HCM, hypertrophic cardiomyopathy; Diabetes, diabetes mellitus; DCM, dilated cardiomyopathy; AV block, atrioventricular block; AF, atrial fibrillation; ICD codes used to define these diseases in Supplementary Data 28.
