Fig. 5: Manhattan plots and quantile-quantile (QQ) plots of the meta-analyses for the age and BMI at adiposity peak and adiposity rebound estimated phenotypes.
From: A framework for conducting GWAS using repeated measures data with an application to childhood BMI
The two-sided association P-value on the –log10 scale obtained from the inverse-variance-weighted fixed-effects meta-analysis for each of the SNPs (y-axis) was plotted against the genomic position (NCBI Build 37; x-axis). Loci are labelled with their nearest gene annotated by LocusZoom. The red dotted line in the Manhattan plots corresponds to the genome-wide significance level of P < 5×10-8, which accounts for multiple testing. The red dots in the QQ plots are the two-sided association P-values, the blue shading represents the 95% confidence bands of the expected values. λgc is the genomic inflation factor.
