Table 1 Scoring matrix for the histology examination
From: Outcome of SARS-CoV-2 reinfection depends on genetic background in female mice
Score | Area affected | Epithelial degeneration/necrosis | Inflammation |
|---|---|---|---|
0 | none | None | None |
1 | 5–10% | Minimal; scattered cell necrosis/vacuolation affecting 5 to 10% of tissue section | Minimal; scattered inflammatory cells affecting 5–10% of tissue section |
2 | 10–25% | Mild; scattered cell necrosis/vacuolation | Multifocal, few inflammatory cells |
3 | 25–50% | Moderate; multifocal vacuolation or sloughed/necrotic cells | Thin layer of cells (<5 cell layer thick) |
4 | 50–75% | Marked; multifocal/segmental necrosis, epithelial loss/effacement | Thick layer of cells (>5 cell layer thick) |
5 | >75% | Severe; coalescing areas of necrosis, parenchymal effacement | Confluent areas of inflammation |
