Fig. 5: Structural analysis of the M1249L D5 ___domain identifies it as a temporary transcription factor with similarities to TFIIS.
From: Transcription regulation of African swine fever virus: dual role of M1249L
a The surface structure of vRNAP-M1249L, highlighting the functional domains of M1249L, shows similarities to the classical transcription factor TFIIS (yellow dashed box). b Comparison of the ___location of M1249L D5 ___domain to S.cerevisiae and human TFIIS. The whole model is shown as half-transparent blue surface with M1249L D5 ___domain or TFIIS shown as solid cartoon. The Zn2+ ions are shown as spheres and highlighted by a blue dashed circle. c The cartoon structures of TFIIS homolog structures from ASFV, S.cerevisiae and human. The Zn2+ ions are shown as spheres. The similar domains are indicated by dashed circles of the same color. d Close-up view shows the key acidic amino acids (…DE…) involved in functional activity with Zn2+ ions. e Three different maps illustrate the M1249L D5 ___domain dynamic alterations.
