Fig. 1: Glutamate-bound and -unbound Best2 structures. | Nature Communications

Fig. 1: Glutamate-bound and -unbound Best2 structures.

From: Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment

Fig. 1

a Side view of glutamate-bound Best2 in the closed state with glutamate molecule shown as blue sticks and Ca2+ as a green sphere. Regions of the AS are colored as follows: ACR1, yellow; Anchor, blue; ACR2, red. PM, plasma membrane. Black box indicates region of focus in panel (b). b Close-up of the glutamate binding site with hydrogen bonds depicted as dotted lines and interacting residue side chains labeled. c The model and map (shown at sigma 6) of the glutamate binding site with Q354 and the bound glutamate labeled. d–f The same format as a–c, respectively, for glutamate-unbound Best2 in the fully open state from the same data set.

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