Fig. 4: Functional influences of small compounds on bestrophin channels. | Nature Communications

Fig. 4: Functional influences of small compounds on bestrophin channels.

From: Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment

Fig. 4

a–d The I-V relationships of Best2 in transiently transfected HEK293 cells at 1 μM [Ca2+]i when the principal anion is Cl− in both internal and external solutions, without (black) or with (red solid) the treatment of 100 μM PABA (a), PNBA (b), isoguvacine (c), or PHBA (d); n = 5–9 for each point; *p < 0.05 compared to untreated cells (black), using two-tailed unpaired Student’s t test. e–h The same format as a–d, respectively, for Best1; n = 6–7 for each point. The chemical structure of each compound is shown in the respective panel in e–h. All error bars in this figure represent s.e.m.

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