Fig. 2: Waterfall plot of change in tumor size; CT and PET images for two patients achieving partial responses; Swimmer’s plot of treatment duration and response.
From: MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial
a Waterfall plot of best percentage change in tumor size by RECIST. b Serial axial CT/PET images of a 54-year-old male patient with high-grade neuroendocrine carcinoma of the lung treated with single agent AG270/S095033 at a dose of 200 mg QD. White arrows indicate ___location of tumor. PR partial response. c Serial axial CT images of a 53-year-old male patient with a refractory sex cord stromal cell cancer treated with single agent AG270/S095033 at a dose of 100 mg QD. White arrows indicate ___location of tumor. PR partial response. d Swimmer’s plot of treatment duration and best response by RECIST. BDC bile duct cancer, MM malignant mesothelioma, NSCLC non-small cell lung cancer, PC pancreatic cancer.
