Fig. 2: C > A mutation spectra and 8-oxodG lesion spectra in human cells under endogenous or KBrO3-induced DNA damage.
From: Contributing factors to the oxidation-induced mutational landscape in human cells
A Comparison of percentages of C > A trinucleotide mutation contexts from COSMIC SBS18 and KBrO3-induced mutations gave a cosine similarity of 0.812 and comparison with endogenous 8-oxodG lesion mapping gave a cosine similarity of 0.867. Comparison of KBrO3-induced mutations with KBrO3-induced 8-oxodG lesions gave a cosine similarity of 0.896. B Differential bar graphs display discrepancies in trinucleotide contexts percentages between SBS18 and KBrO3 mutations has a cosine similarity of 0.908 compared to the differential bar graphs displaying discrepancies between trinucleotide contexts from endogenous 8-oxodG lesions compared to endogenous KBrO3-induced 8-oxodG lesions.
