Fig. 5: KBrO3-induced mutagenesis in human WT, POLH-/-, or HMCES-/- RPE-1 cells lines.
From: Contributing factors to the oxidation-induced mutational landscape in human cells
A Number of SNVs and INDELs per genome in KBrO3-treated for WT (n = 4), POLH-/- (n = 1), and HMCES-/- (n = 6) RPE-1 cells lines. Circles indicate independent genomes sequenced and horizontal bars are median values. Raw sequencing of the POLH-/- cell line obtained from50 was also reprocessed (indicated with an *) using BWA-mem and the consensus variant calling pipeline employed for the WT and HMCES-/- cells. KBrO3-associated B SNV and C INDEL mutation signatures from treated genomes.
