Fig. 7: Mechanisms that limit KBrO3-induced 8-oxodG mutagenesis in human cells.
From: Contributing factors to the oxidation-induced mutational landscape in human cells
Mutations from 8-oxoG can be limited in human cells by OGG1- and MUTYH-initiated BER. Secondary limits on mutagenesis include Pol η, HMCES, and transcription-coupled repair. Dashed lines represent multi-step processes. Image created with BioRender.com under agreement number DX26OBAXYI.
