Fig. 6: hORC-hCDC6 in the hOCCM structure.

a Domain organisation of hORC1-5 and hCDC6 proteins, and b Organisation of the AAA+ and Winged Helix Domains of the DNA-bound hORC1-5-hCDC6 ring in the hOCCM. c Comparison of hORC1-5-hCDC6 ring in the hOCCM (coloured) with human hORC1-5-DNA structure (grey, PDB: 7JPS). d Reorganisation of hORC5 WHD in hOCCM when compared to hORC1-5-DNA structure (grey, PDB: 7JPS). e hORC2 (purple) and hORC3 (red) become reorganised to accommodate hCDC6 in the hOCCM structure compared to the hORC1-5-DNA only structure (grey, PDB: 7JPS). f No hORC6 densities were observed in the hOCCM, while yOrc6 was observed in yOCCM (blue, PDB: 5V8F) and DmOrc6 in the active DmOrc1-5 structure (green, PDB:7JK6). Human, yeast and Drosophila models were aligned by ORC3. Experimental densities were downloaded from the EMDB and aligned. The Orc6 densities from yeast and Drosophila were segmented by a radius of 4 Å and gaussian filtered by 1.5 Å (grey) to display experimental Orc6 position relative to the hOCCM density (coloured).