Fig. 3: The loop DSB is required for enhancement of AMPAR activation by TARPγ2. | Nature Communications

Fig. 3: The loop DSB is required for enhancement of AMPAR activation by TARPγ2.

From: Structure of transmembrane AMPA receptor regulatory protein subunit γ2

Fig. 3

a Schematic representation of the GluA2 (blue)-TARPγ2 (cyan) fusion construct used for electrophysiology demonstrating the ___location of the ΔDSB mutation (pink). b Representative traces, c current densities (two-tailed Welch’s t-test, p = 0.0026), d percentages of desensitization (two-tailed Welch’s t-test, p = 0.0014) and e time constants of desensitization kinetics of AMPARs complexed with either WT or ΔDSB TARPγ2 during a 500 ms exposure to 1 mM Glutamate (two-tailed Welch’s t-test, p = 0.33). WT, black, n = 13; ΔDSB, pink, n = 9; Bars represent mean ± SEM; **p < 0.01. Source data are provided as a Source Data File.

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