Fig. 1: Sex biases identified in inadequately host-filtered human tumor tissue data. | Nature Communications

Fig. 1: Sex biases identified in inadequately host-filtered human tumor tissue data.

From: Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data

Fig. 1

a RPCA of microbial relative abundance quantification from tumor samples in the Hartwig Medical Foundation Database, which was originally subject to GRCh38.p7 filtration exclusively. Statistically significant differences were found between male and female groups (PERMANOVA; pseudo-F = 65.4, p = 0.00025). b Identical dataset and pre-processing steps done in a but with the addition of the T2T-CHM13v2.0 reference genome in host filtration. Differences were not statistically significant between male and female groups (PERMANOVA; pseudo-F = 1.23, p = 0.29).

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