Fig. 2: Host filtration pipeline and runtime evaluation.

a Pipeline of host filtration methods. b Using simulated data with a 50/50 mix of human data from HPRC and microbial data from FDA-ARGOS, we applied the 3 host filtration methods with 3 different sample sizes. Runtimes were averaged across 10 runs per sample size. HG38: GRCH38.p14, T2T: T2T-CHM13v2.0, HPRC: Human Pangenome Reference Consortium 2024 release.