Fig. 2: L. reuteri ZJ617 re-programs gut microbiota composition of HFD-fed mice.
From: Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine
Microbiota composition of LFD, HFD, and HFD + ZJ617 was analyzed by 16S rDNA (n = 9 per group). a Unweighted UniFrac PCoA analysis of gut microbiota. b Unweighted UniFrac distance of gut microbiota. c Phylum taxonomic level. d Firmicutes to Bacteroidetes (F/B) ratio. e The changing direction of the 45 ASVs by L. reuteri ZJ617 according to random forests classifier. Circles represent less abundant ASVs in LFD and L. reuteri ZJ617 relative to the HFD group; Black dots indicate higher abundances of ASVs in LFD and L. reuteri ZJ617 relative to the HFD group. The taxonomy of the ASVs (genus, family, and phylum) are shown on the right. The box plots shown as minima, maxima, center, bounds of box and whiskers, and percentile. Significance in (b) is calculated based on two-tailed PERMANOVA with pseudo-F tests. Data in (d) are shown as mean ± SD, and significance is calculated based on one-way ANOVA with Kruskal–Wallis tests for multiple-group comparisons.
